Silver Alginate Dressing
  • 产品名称: Silver Alginate Dressing
  • 产品编号: A-001

LUOFUCON Silver Alginate Dressing

 

Product Description

LUOFUCON™Silver Alginate Dressing is a non-woven pad composed of calcium alginate and silver particles. The silver content is 50µg/100 cm2. The silver particles are in the form of encapsulated metallic silver, which is very stable and won’t be oxidized even on exposure to light.

LUOFUCON™ Silver Alginate Dressing is proved to have broad spectrum antibacterial effect , based on in vitro laboratory testing.

 

1. Silver Release

Figure1 shows that LUOFUCON™ Silver Alginate Dressing leaches about 57% of the total silver during the first 24 hours, and 30%, 24% of its total silver during 24-48, 48-72 hours, respectively.

The release profiles indicates that the release of silver from the dressing is well controlled.

Note:

Two pieces of the dressing in the size of 10 x 10 cm were used in this test. The test was performed by China National Analytical Center at Guangzhou.

 

 

2. Antibacterial Activity

2.1 Comparative Test

One representative Gram-positive bacteria(Staphylococcus aureus) and one representative Gram-negative bacteria(Pseudomonas aeruginosa) were tested under AATCC 100-2004.

Figure 2 and Figure 3 show LUOFUCON™ Silver Alginate Dressing has four log reduction (99.99%)for both organisms, the other two products only have three log reduction (99.9%).

 

Figure 2 Log Reduction - Staphylococcus aureus    Figure 3 Log Reduction - Pseudomonas aeruginosa

Note: Comparison 1 and 2 are other silver alginate dressings in the market. The test was performed by our own laboratory.

 

2.2  Antibacterial Effectiveness Test

AATCC 100-2004 only specifies the use of one Gram-positive and one Gram-negative bacteria. However, we tested six clinical-relevant bacteria ( 3 Gram-positive and 3 Gram-negative bacteria) for the evaluation of antibacterial effectiveness.

 

Test Organism Test Method
Enterococcus faecalis ATCC 29219 Dressing specimens and controls were tested under simulated use conditions for seven days. During this time, test articles were kept moistened daily with phosphate buffered water containing 10% Fetal Bovine Serum to simulate daily use. The antibacterial activity testing was performed with an inoculum challenge of more than 106 CFU total.
Escherichia coli ATCC 8739
Klebsiella pneumoniae ATCC 4352
Pseudomonas aeruginosa ATCC 9027
Staphylococcus aureus ATCC 6538
Streptococcus pyogenes ATCC 19615

 

Figure 4 Antibacterial Effectiveness(GLP Study)

At day-1, results show LUOFUCON™ Silver Alginate Dressing has bacteria reduction of at least four log reduction for all six test organisms;

 

At day-7, bacteria reduction for all the organisms is at least two log reduction(data in table 1 and table 2).

 

Note:The test was performed under Good Laboratory Practice regulations, by WuXi AppTec, Inc.(Address :1265 Kennestone Circle, Marietta, GA 30066).

 

Based on the test results, LUOFUCON™ Silver Alginate Dressing has broad spectrum antibacterial effect for Gram-positive and Gram-negative bacteria.

 

 Table 1: 1 Day Antibacterial Effectiveness

    1 Day
  Replicate 1 Replicate 2 Replicate 3
Staphylococcus aureus >4.0 >4.1 >4.1
Streptococcus pyogenes >4.4 >4.4 >4.3
Enterococcus faecalis >4.3 >4.2 >4.3
Escherichia coli >4.2 >4.2 >4.13
Klebsiella pneumoniae >4.1 >4.0 >4.1
Pseudomonas aeruginosa >4.1 >4.1 >4.1

 

 Table 2: 7 Days Antibacterial Effectiveness

  7 Day
  Replicate 1 Replicate 2 Replicate 3
Staphylococcus aureus >4.0 >4.0 >4.0
Streptococcus pyogenes >4.1 >4.1 >4.1
Enterococcus faecalis 2.1 1.6 2.6
Escherichia coli >4.3 >4.3 >4.3
Klebsiella pneumoniae >4.2 >4.2 >4.2
Pseudomonas aeruginosa >4.0 >4.0 >4.0

 

2.3 Additional Study

Besides the six clinical-relevant bacteria above, we made an additional study for one drug-resistant bacteria(MRSA) and one fungus(Candida albicans).

 

Figure 5 Antibacterial Effectiveness(Additional Study)

Figure 5 shows LUOFUCON™ Silver Alginate Dressing has at least two log reduction for both MRSA and Candida albicans , during the first 24 hours.

 

Note:The test was performed by Guangdong Detection Center of Microbiology at Guangzhou.

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